Trinkets can give you buffs passively or when activated in The Binding of Issac: Rebirth. Naturally, you can only hold one trinket at a time but have two trinkets simultaneously after acquiring the Mom’s Purse item. Trinkets that need activation can be activated after pressing the left ctrl button on the PC and the left joystick trigger on consoles. I will list all the Trinkets in the game further in the guide.
Trinkets
???’s Soul: Creates a familiar that moves around the room diagonally, shooting homing tears in the same direction as the player. All familiars the player has will follow ???’s Soul instead of the player. Unlocked by beating The Dark Room floor with Blue Baby.
Ace of Spades: There is a higher chance to find Tarot Cards.
AAA Battery: Lowers your spacebar item total charges by 1.
Black Lipstick: Evil Up. Unlocked by beating The Dark Room with Eve.
Bible Tract: Faith Up.
Bloody Penny: Every time you pick up a coin, you can spawn a red heart. Unlocked by beating The Chest with Samson.
Broken Ankh: Unknown. Unlocked by beating Satan with Lazarus.
Broken Magnet: Partial Magneto effect attracts coins, pulling them to the player from a distance.
Broken Remote: Teleports you every time you use a spacebar item.
Burnt Penny: Every time you pick up a coin, there is a chance a bomb will be spawned. Unlocked by beating Challenge 13.
Butt Penny: Every time you pick up a coin, you fart.
Cain’s Eye: Upon entering a room, you can view all map icons for the floor (The Compass effect). Unlocked by beating The Chest with Cain.
Callus: The player cannot take damage from spikes or blood trails.
Cancer: Tears Up.
Cartridge: Chance for the player to have the Gamekid effect, turning them invincible and dealing contact damage whenever they get hit.
Child’s Heart: Higher chance to find hearts.
Counterfeit Penny: When the player picks up a coin, they might gain one more coin automatically. Unlocked by playing the Skull Game 100 times.
Cursed Skull: When the player takes damage while on 1/2 a red heart or less, they are teleported back to the previous room.
Curved Horn: Damage Up.
Daemon’s Tail: Higher chance to find Black Hearts. Unlocked by beating Satan with Azazel.
Eve’s Bird Foot: Chance to spawn a Dead Bird familiar while in combat. Unlocked by beating Isaac with Eve.
Fish Head: Spawns a blue fly when the player takes damage.
Flat Penny: Chance to spawn a key when picking up a coin.
Flat Worm: Tears become flat discs and have higher knockback.
Goat Hoof: Speed Up.
Hook Worm: Tears shift left and right across the room.
Isaac’s Fork: Chance to heal half a heart after clearing a room.
Isaac’s Head: Gives the player a familiar that shoots normal tears. Unlocked by beating the Boss Rush Room with Isaac.
Judas’ Tongue: Items that cost two heart containers in the Devil Room are reduced to 1. Unlocked by beating Satan with Judas.
The Left Hand: All chests become red chests. Unlocked by killing Ultra Pride.
Liberty Cap: Random mushroom effect in each room. Includes mini mushrooms, odd mushrooms (thin and thick), and magic mushrooms.
Lucky Toe: Enemies are more likely to drop items or pick-ups. Unlocked by blowing up 20 of the little people found in Shops or Secret Rooms.
Lucky Rock: Rocks drop money when broken. Unlocked by destroying 100 rocks.
Maggy’s Faith: The player gains an eternal heart at the start of each new floor. Unlocked by beating The Dark Room with Maggy.
Match Stick: Higher chance to find bombs.
A Missing Page: The Chance to damage the entire room in a Necronomicon-like effect when the player gets hit.
Missing Poster: Dying in a sacrifice room will reveal a puzzle piece on the death screen. Finding all the pieces will help unlock the character, “The Lost.” Unlocked by beating The Dark Room with Isaac.
Mom’s Pearl: A higher chance to find soul’s hearts.
Mom’s Toenail: Mom’s Leg will appear every 60 seconds and stomp randomly inside the current room. It can also hurt the player.
Monkey Paw: A black heart will spawn when the player reaches half a red heart. The trinket disappears after three black hearts.
Mysterious Candy: The player will poop randomly.
Mysterious Paper: Enemies have a chance to drop half-red hearts. Dying in a sacrifice room will reveal a puzzle piece on the death screen. Finding all the pieces will help unlock the character, “The Lost.” Unlocked by beating The Dark Room with Eden.
Paper Clip: Golden Chests can sometimes be unlocked for free.
Petrified Poop: Poop has a higher drop rate of pick-ups.
Pinky Eye: Chance for tears to poison enemies.
Pulse Worm: Tears shrink and grow, modifying the damage based on size.
Purple Heart: A higher chance for champion enemies to spawn.
Push Pin: Chance for tears to be spectral and piercing.
Red Patch: Chance to get a Damage Up when taking damage.
Ring Worm: Tears move in a spiral pattern across the screen.
Rosary Bead: Faith Up.
Rusty Key: There is a higher chance of finding keys and chests.
Safety Cap: A higher chance of finding pills.
Samson’s Lock: When the player kills an enemy, they can get a Damage Up for the current room. Unlocked by beating The Dark Room with Samson.
Stored Credit: All items in the Shop cost 0 coins. After buying any item in the Shop, the trinket disappears.
Swallowed Penny: A coin or two will drop each time the player is hit. Unlocked by beating Challenge 15.
Tick: Bosses have 15% less health, and the player restores one red heart upon entering a boss room. It cannot be removed or replaced.
Umbilical Cord: When the player reaches half a heart, a Little Steve familiar spawns.
Whip Worm: Shot Speed Up.
Wriggle Worm: Tears move in a wave fashion across the screen—tears Up.
